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Clinical Neurobiology Laboratory

Transcriptional effects of antidepressants

Nashat Abumaria


Transcriptional effects of chronic social stress and antidepressants

A collaborative project within the CMPB at the University of Göttingen



Molecular events that occur during subtraction cDNA hybridization procedure

 

Despite the fact that antidepressants are widely used in clinical psychiatry the exact molecular mechanisms underlying the lag-phase in their actions are still unknown. Candidate genes that contribute to the symptoms of depression can be identified through analysis of differential gene expression. We are studying mRNA and protein expression in the brains of stressed animals because it is known that in humans, stress can lead to depressive diseases. The stress-induced behavioral symptoms in these animals are similar to those observed in depressed human patients. We also treat animals with antidepressants to find out which candidate genes are regulated by the drugs (see Abumaria et al. 2006; Alfonso et al., 2004).

 

 






Techniques: 
Subtractive cDNA hybridization, Real time PCR, Western blotting, in situ hybridization, immunocytochemistry

 
© 09.01.12  Clinical Neurobiology Laboratory
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