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Clinical Neurobiology Laboratory

Neuronal structure

Claudia Perez-Cruz


Morphology of pyramidal neurons in the prefrontal cortex

We use whole cell patch-clamping combined with neurobiotin injection for the study of pyramidal cell morphology in the rat prefrontal cortex.
 

The rat prefrontal cortex (PFC) can be considered to be analogous to the human PFC regarding neuronal connections with medial thalamic nuclei and other subcortical areas.
The rat PFC is subdivided into three main subfields: prelimbic, infralimbic, and anterior cingulate cortex. These subfields seem to have functional dissimilarities and it has been suggested that they are lateralized. Until now, however, there are no data concerning morphological differences in pyramidal cells between these subfields of the right and the left PFC.

 

Techniques:
Immunocytochemistry, intracellular neuronal labeling, electrophysiology

 
© 09.01.12  Clinical Neurobiology Laboratory
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