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Clinical Neurobiology Laboratory

Neurogenomics

Gabriele Flügge


Neurogenomics

© 2005
Neurons in the amygdala that express the serotonin-1A receptor (black dots) and contain parvalbumin (brown color). Combination of in situ hybridization and immunocytochemistry.

 

Central nervous disorders such as depression can be induced by stress and there is evidence that changes in neuronal and glial brain structures constitute the neurobiological basis for certain psychopathologies. To elucidate the underlying molecular mechanisms, we are investigating gene expression in stressed animals and controls (Abumaria et al., 2006; e.g. Alfonso et al., Eur J Neurosci, 2004). In addition, we are studying gene expression in brains of animals that are treated with antidepressants. One effect of stress that might contribute to psychopathologies is alterations in expression of monoamine receptors in certain brain regions (see Flügge et al., Cell & Tiss Res, 2004).

 

Techniques:
In situ hybridization, immunocytochemistry, confocal microscopy, in vitro receptor autoradiography

 
© 09.01.12  Clinical Neurobiology Laboratory
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