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Clinical Neurobiology Laboratory

Multiple sclerosis

Eberhard Fuchs


Modeling multiple sclerosis in marmoset monkeys

 

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which predominantly affects young adults during their most productive years. Viral and autoimmune etiologies are postulated. Genetic and environmental factors are known to contribute to MS, but a specific cause for this disease is not identified. Since no curative treatment for MS is available yet the development for effective therapies created a need for valid preclinical animal models. The wide immunological gap between man and laboratory rodents (rat or mouse) makes many disease models in these species invalid. The immunological similarity of marmoset monkeys and man together with the clinical and neuropathological similarity of the experimental autoimmune encephalitis (EAE) model in marmosets and MS provide a unique experimental platform for research on the development of more effective treatments of MS (see Merkler et al. 2006; Boretius et al., 2006).

 
© 09.01.12  Clinical Neurobiology Laboratory
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