| Contact us | Internal | People |
| 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 |
| Home | Contact us | Impressum |

Clinical Neurobiology Laboratory

Neurogenesis

Boldizsár Czéh


Neurogenesis and neuroplasticity



A newborn neuron (BrdU-labeled, yellow) among
the granule cells (NeuN, green) in the dentate gyrus

 

Adaptations at the cellular and molecular level in response to stress and antidepressant treatment could represent a form of neural plasticity that contributes to the pathophysiology or the treatment of depression. Retraction of dendrites in stress-vulnerable neurons as well as decreased neurogenesis in the hippocampal formation has been reported in preclinical studies.
Clinical studies provide evidence for shrinkage of the hippocampus and the prefrontal cortex. It is hypothesized that antidepressant treatment could oppose these adverse effects. We are testing this hypothesis in an animal model for depression, the chronic psychosocial stress paradigm in male tree shrews.

 

Techniques:
Immunocytochemistry, confocal microscopy, stereology

 
© 09.01.12  Clinical Neurobiology Laboratory
| Top |